β-arrestin Recruitment Assay

Област/Соседство: New York

β-Arrestins bind to GPCRs in a conformationally sensitive manner and are known to regulate: 1) GPCR desensitization by inhibition of GPCR coupling to heterotrimeric G proteins, 2) GPCR endocytosis by promoting association of GPCR/β-arrestin complexes, and (3) arrestin-promoted signaling via the extensive adaptor functions of the β-arrestins. The β-arrestin-mediated signaling constitutes an important component of GPCR signaling in addition to the G protein-mediated signaling. Monitoring of β-arrestin recruitment to activated receptors has become a popular way to measure GPCR activity and is described as a ‘universal’ GPCR platform owing to the fact that it is G-protein independent, such that GPCRs will recruit β-arrestins regardless of the nature of the G protein to which they couple.

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