Ip3 Assay

Område/Trakt: New York

GPCRs transmit information within cells via two major signaling pathways: regulation of cAMP levels and increases in intracellular Ca2+ triggered by inositol 1, 4, 5- triphosphate (IP3). These signaling pathways are activated by specific G protein associated with the receptor. Activation of Gs or Gi coupled receptor results in an increase or decrease in cAMP levels, respectively. While activation of Gq coupled receptor activates phospholipase C (PLC), which converts PIP2 into DAG and IP3. The metabolic pathway of IP3 is very complicated, as IP3 can either be directly hydrolyzed or be first phosphorylated to generate D-myo-inositol 1, 3, 4, 5-tetrakisphosphate (IP4) before being degraded.

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